Aleah Caulin
- Program Years: 2010-2014
- Academic Institution: University of Pennsylvania
- Field of Study: Genomics and Computational Biology
- Academic Advisor: Carlo Maley
- Practicum(s):
Lawrence Berkeley National Laboratory (2012) - Degree(s):
B.S. Biology, Boston College, 2008
Ph.D. Genomics and Computational Biology, Upenn
Current Status
- Status: Director of Preclinical Studies at PEEL Therapeutics
- Research Area: Oncology
Publications
Fox, Aleah K, Tuch, Brian B, Chuang, Jeffrey H. Measuring the prevalence of regional mutation rates: an analysis of silent substitutions in mammals, fungi, and insects. BMC Evolutionary Biology 2008, 8:186.Caulin, Aleah F and Maley, Carlo C. Peto's Paradox: Evolution's Prescription for Cancer Prevention. Trends in Ecology and Evolution, (2011) Vol 26 Issue 4, pp. 175-182.
Benjamin Roche, Michael E. Hochberg, Aleah F. Caulin, Carlo C. Maley, Robert A. Gatenby, Dorothee Misse, Frederic Thomas. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer 2012, 12:387.
Liu N, Caulin AF, Graham T, Jablons D, Maley CC. Within-tumor genetic diversity in lung cancer. Journal of the American College of Surgeons. 2012, 215(3), pp. S38.
Caulin AF, Graham TA, Wang L-S, Maley CC. Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis. Philosophical Transactions of the Royal Society B: Biological Sciences. 2015;370(1673):20140222.
Lisa M. Abegglen, Aleah F. Caulin, Ashley Chan, Kristy Lee, Rosann Robinson, Michael S. Campbell, Wendy K. Kiso, Dennis L. Schmitt, Peter J. Waddell, Srividya Bhaskara, et al. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA. 2015 November 3; 314(17) doi: 10.1001/jama.2015.13134
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
Collin M. Blakely, Thomas B.K. Watkins, Wei Wu, Beatrice Gini, Jacob J. Chabon, Caroline E. McCoach, Nicholas McGranahan, Gareth A. Wilson, Nicolai J. Birkbak, Victor R. Olivas, Julia Rotow, Ashley Maynard, Victoria Wang, Matthew A. Gubens, Kimberly C. Banks, Richard B. Lanman, Aleah F. Caulin, John St. John, Anibal R. Cordero, Petros Giannikopoulos, Andrew D. Simmons, Philip C. Mack, David R. Gandara, Hatim Husain, Robert C. Doebele, Jonathan W. Riess, Maximilian Diehn, Charles Swanton, Trever G. Bivona
Nat Genet. 2017 Dec; 49(12): 1693-1704. Published online 2017 Nov 6. doi: 10.1038/ng.3990
Tollis M, Robbins J, Webb AE, Kuderna LFK, Caulin AF, Garcia JD, Bèrubè M, Pourmand N, Marques-Bonet T, O'Connell MJ, Palsbøll PJ, Maley CC. Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae). Mol Biol Evol. 2019 Aug 1;36(8):1746-1763. doi: 10.1093/molbev/msz099. PMID: 31070747; PMCID: PMC6657726.
Merlo LMF, Sprouffske K, Howard TC, Gardiner KL, Caulin AF, Blum SM, Evans P, Bedalov A, Sniegowski PD, Maley CC. Application of simultaneous selective pressures slows adaptation. Evol Appl. 2020 Aug 15;13(7):1615-1625. doi: 10.1111/eva.13062. PMID: 32952608; PMCID: PMC7484835.
Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood. 2020 Sep 3;136(10):1169-1179. doi: 10.1182/blood.2020007008. PMID: 32597954; PMCID: PMC7472714.
Awards
Excellence in Genome Science Frontiers Award 2008Cum laude May 2008
Accepted to Honors Biology Program, Boston College, Sept 2007
Society of Molecular Biology and Evolution Undergraduate Diversity Award 2007