Bree Aldridge
- Program Years: 2002-2006
- Academic Institution: Massachusetts Institute of Technology
- Field of Study: Computational Biology
- Academic Advisor: Douglas Lauffenburger
- Practicum(s):
Pacific Northwest National Laboratory (2004) - Degree(s):
Ph.D. Biological Engineering, Massachusetts Institute of Technology, 2008
B.S. Computer Engineering, University of Arizona, 2002
B.S. Molecular and Cellular Biology, University of Arizona, 2002
Current Status
- Status: Assistant Professor, Tufts University
- Research Area: Systems Biology/Computational Biology
- Personal URL: http://openwetware.org/wiki/Bree_Aldridge
Publications
Wirth, S.E., Krywy, J.A., Aldridge, B.B., Fortune, S.M., Fernandez-Suarez, M., Gray, T.A., Derbyshire, K.M., "Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.†Molecular Microbiology, 2012, 83(3):654-664.Aldridge, B.B.*, Fernandez-Suarez, M.*, Heller, D., Ambravaneswaran, V., Irimia, D., Toner, M., Fortune, S.M., “Asymmetry and aging in mycobacterial cells lead to variable growth and antibiotic susceptibility.†Science, 2012, 335 (6064): 100-104.
Aldridge, B.B.*, Gaudet, S.*, Lauffenburger, D.A., Sorger, P.K., “Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.†Molecular Systems Biology, 2011, 7:553.
Aldridge, B.B., Saez-Rodriguez, J., Muhlich, J.L., Sorger, P.K., Lauffenburger, D.A., Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/Insulin-induced signaling. PLoS Computational Biology, 2009, 5(4): e1000340.
Albeck, J.G., Burke, J.M., Aldridge, B.B., Zhang, M.S., Lauffenburger, D.A., Sorger, P.K. €œQuantitative analysis of pathways controlling extrinsic apoptosis in single cells.†Mol. Cell, 2008, 30(1):11-25.
Aldridge, B.B., Burke, J., Lauffenburger, D., Sorger, P. €œPhysicochemical Modelling of Cell Signaling Pathways.†Nature Cell Biol, 2006, 8:1195-2003.
Aldridge, B.B., Haller, G., Sorger, P., and Lauffenburger, D. “Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.†Systems Biology, 2006. 153 (6).
Draviam VM, Shapiro I, Aldridge B., and Sorger PK. €œMisorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.†EMBO Journal, 2006. 25 (12): 2814-27.