Practicum Experience(s)
Argonne National Laboratory (2024)
Summary of Research
Michelle Garcia is a graduate student at Dartmouth College studying theoretical and computational chemistry. She utilizes computer simulations to understand the mechanisms by which small molecule drugs bind intrinsically disordered proteins (IDPs), a challenging class of drug target associated with many currently untreatable neurodegenerative diseases and cancers. Michelle's research combines mathematical methods from topology and differential geometry with machine learning techniques to characterize IDP drug binding modes and inform the design of more potent inhibitors.
Annual Program Review Abstracts
Publications
Anthony K.N. Chan et al. ,Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery.Sci. Adv.10,eadk3127(2024).DOI:10.1126/sciadv.adk3127
(I am 10th author on this paper)
Garcia, M.; O'Leary, F.; O'Leary, D. Do-It-Yourself 5-Color 3D Printing of Molecular Orbitals and Electron Density Surfaces Journal of Chemical Education 2023 100 (4), 1648-1658
DOI: 10.1021/acs.jchemed.2c00907
Liu, Q.; Garcia, M.; Wang, S.; Chen, C.-W. Therapeutic Target Discovery Using High-Throughput Genetic Screens in Acute Myeloid Leukemia. Cells 2020, 9, 1888. https://doi.org/10.3390/cells9081888
Caltech Summer Research Presentations 2020
SACNAS 2020
ABRCMS 2020
Computational Aspects of Biomolecular NMR Gordon Research Conference 2023
Awards
Undergraduate
Academic Honors
Phi Beta Kappa, Amgen Scholar, Barry M. Goldwater Scholar, American Chemical Society Scholar
Academic Awards
Hispanic Scholarship Fund Scholar, QuestBridge Scholar, Zenith scholar, The Robert Rowan III ('68) Memorial Award in Chemistry